abstract：:Bacterial infections pose a challenge to human health and burden the health care system, especially with the spread of antibiotic-resistant populations. To provide effective treatment and improved prognosis, effective diagnostic methods are of great importance. Here we present phage-mediated molecular detection (PMMD)...

journal_title：Viruses

authors： Malagon F,Estrella LA,Stockelman MG,Hamilton T,Teneza-Mora N,Biswas B

更新日期：2020-04-11 00:00:00

abstract：:Bats provide important ecosystem services as pollinators, seed dispersers, and/or insect controllers, but they have also been found harboring different viruses with zoonotic potential. Virome studies in bats distributed in Asia, Africa, Europe, and North America have increased dramatically over the past decade, wherea...

journal_title：Viruses

authors： Bolatti EM,Zorec TM,Montani ME,Hošnjak L,Chouhy D,Viarengo G,Casal PE,Barquez RM,Poljak M,Giri AA

更新日期：2020-04-09 00:00:00

abstract：:Aplastic anemia is a rare blood disease characterized by the destruction of the hematopoietic stem cells (HSC) in the bone marrow that, in the majority of cases, is caused by an autoimmune reaction. Patients with aplastic anemia are treated with immunosuppressive drugs and some of them, especially younger individuals ...

journal_title：Viruses

authors： Inoue H,Rai S,Tanaka H,Espinoza JL,Komori-Inoue M,Kakutani H,Minamoto S,Kumode T,Nakayama S,Taniguchi Y,Morita Y,Okuda T,Tatsumi Y,Ashida T,Matsumura I

更新日期：2020-04-08 00:00:00

abstract：:Porcine endogenous retroviruses (PERVs) are integrated in the genome of pigs and are transmitted like cellular genes from parents to the offspring. Whereas PERV-A and PERV-B are present in all pigs, PERV-C was found to be in many, but not all pigs. When PERV-C is present, recombination with PERV-A may happen and the P...

journal_title：Viruses

authors： Krüger L,Stillfried M,Prinz C,Schröder V,Neubert LK,Denner J

更新日期：2020-04-08 00:00:00

abstract：:In the midst of the SARS-CoV-2/Covid-19 outbreak the need for research into, and development of, antiviral agents is brought into sharp focus worldwide for scientists, governments and the public alike [...]. ...

journal_title：Viruses

authors： Adamson CS

更新日期：2020-04-07 00:00:00

abstract：:Bacterial biofilm prevention and eradication are common treatment problems, hence there is a need for advanced and precise experimental methods for its monitoring. Bacterial resistance to antibiotics has resulted in an interest in using a natural bacterial enemy-bacteriophages. In this study, we present the applicatio...

journal_title：Viruses

authors： Guła G,Szymanowska P,Piasecki T,Góras S,Gotszalk T,Drulis-Kawa Z

更新日期：2020-04-07 00:00:00

abstract：:A highly virulent porcine epidemic diarrhea virus (PEDV) appeared in China and spread rapidly to neighbor countries, which have led to great economic losses to the pig industry. In the present study, we isolated a PEDV using Vero cells and serially propagated 100 passages. PEDV SDSX16 was characterized in vitro and in...

journal_title：Viruses

authors： Zhao P,Wang S,Chen Z,Yu J,Tang R,Qiu W,Zhao L,Liu Y,Guo X,He H,Xu G,Li J,Wu J

更新日期：2020-04-01 00:00:00

abstract：:MicroRNAs (miRNAs) are non-coding but functional RNA molecules of 21-25 nucleotides in length. MiRNAs play significant regulatory roles in diverse plant biological processes. In order to decipher the relationship between nbe-miR1919c-5p and the accumulations of tobacco curly shoot virus (TbCSV) and its betasatellite (...

journal_title：Viruses

authors： Du J,Wu R,Liu Z,Sun M,Ghanem H,Li M,Wu G,Qing L

更新日期：2020-04-01 00:00:00

abstract：:Autophagy and apoptosis are two important evolutionarily conserved host defense mechanisms against viral invasion and pathogenesis. However, the association between the two pathways during the viral infection of T lymphocytes remains to be elucidated. Simian type D retrovirus (SRV) is an etiological agent of fatal sim...

journal_title：Viruses

authors： Zhu J,Yang L,Zhang Q,Meng J,Lu ZL,Rong R

更新日期：2020-03-31 00:00:00

abstract：:Deoxynucleoside triphosphate (dNTP) molecules are essential for the replication and maintenance of genomic information in both cells and a variety of viral pathogens. While the process of dNTP biosynthesis by cellular enzymes, such as ribonucleotide reductase (RNR) and thymidine kinase (TK), has been extensively inves...

journal_title：Viruses

authors： Coggins SA,Mahboubi B,Schinazi RF,Kim B

更新日期：2020-03-31 00:00:00

abstract：:Influenza A viruses (IAVs) are highly contagious pathogens infecting human and numerous animals. The viruses cause millions of infection cases and thousands of deaths every year, thus making IAVs a continual threat to global health. Upon IAV infection, host innate immune system is triggered and activated to restrict v...

journal_title：Viruses

authors： Zhang Y,Xu Z,Cao Y

更新日期：2020-03-29 00:00:00

abstract：:The outbreak of emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) in China has been brought to global attention and declared a pandemic by the World Health Organization (WHO) on March 11, 2020. Scientific advancements since the pandemic of severe acute respiratory syndrome (SARS)...

journal_title：Viruses

authors： Jin Y,Yang H,Ji W,Wu W,Chen S,Zhang W,Duan G

更新日期：2020-03-27 00:00:00

abstract：:Emerging viruses have caused concerns about pollinator population declines, as multi-host RNA viruses may pose a health threat to pollinators and associated arthropods. In order to understand the ecology and impact these viruses have, we studied their host range and determined to what extent host and spatial variation...

journal_title：Viruses

authors： Dobelmann J,Felden A,Lester PJ

更新日期：2020-03-24 00:00:00

abstract：:RNA secondary structures play diverse roles in positive-sense (+) RNA virus infections, but those located with the replication protein coding sequence can be difficult to investigate. Structures that regulate the translation of replication proteins pose particular challenges, as their potential involvement in post-tra...

journal_title：Viruses

authors： Sun R,Zhang S,Zheng L,Qu F

更新日期：2020-03-22 00:00:00

abstract：:At present, the clinical detection method of human papillomavirus (HPV) is mainly based on the PCR method. However, this method can only be used to detect HPV DNA and HPV types, and cannot be used to accurately predict cervical cancer. HPV16 E7 is an oncoprotein selectively expressed in cervical cancers. In this study...

journal_title：Viruses

authors： Hu R,Dong Z,Zhang K,Pan G,Li C,Cui H

更新日期：2020-03-19 00:00:00

abstract：:Peptides derived from the C-terminal heptad repeat (CHR) region of HIV-1 gp41 is potent viral membrane fusion inhibitors, such as the first clinically approved peptide drug T20 and a group of newly-designed peptides. The resistance profiles of various HIV-1 fusion inhibitors were previously characterized, and the seco...

journal_title：Viruses

authors： Yu D,Su Y,Ding X,Zhu Y,Qin B,Chong H,Cui S,He Y

更新日期：2020-03-18 00:00:00

abstract：:The honey bee queen is the central hub of a colony to produce eggs and release pheromones to maintain social cohesion. Among many environmental stresses, viruses are a major concern to compromise the queen's health and reproductive vigor. Viruses have evolved numerous strategies to infect queens either via vertical tr...

journal_title：Viruses

authors： Amiri E,Strand MK,Tarpy DR,Rueppell O

更新日期：2020-03-17 00:00:00

abstract：:Avian influenza virus (AIV) is a highly diverse and widespread poultry pathogen. Itsevolution and adaptation may be affected by multiple host and ecological factors, which are stillpoorly understood. In the present study, a turkey-origin H9N2 AIV was used as a model toinvestigate the within-host diversity of the virus...

journal_title：Viruses

authors： Świętoń E,Tarasiuk K,Olszewska-Tomczyk M,Iwan E,Śmietanka K

更新日期：2020-03-16 00:00:00

abstract：:Persistent infection by human papillomaviruses (HPVs), small, double-stranded DNA viruses that infect keratinocytes of the squamous epithelia, can lead to the development of cervical and other cancers. The viral oncoprotein E7 contributes to viral persistence in part by regulating host gene expression through binding ...

journal_title：Viruses

authors： Rice S,Kim SM,Rodriguez C,Songock W,Raikhy G,Lopez R,Henderson L,Yusufji A,Bodily J

更新日期：2020-03-13 00:00:00

abstract：:African swine fever is a highly lethal hemorrhagic fever of Suidae, threatening pig production globally. Suidae can be infected by different ways like ingestion of contaminated feed, direct contact with infected animals or fomites, and biting by infected soft tick bites. As already described, European soft ticks (Orni...

journal_title：Viruses

authors： Pereira De Oliveira R,Hutet E,Duhayon M,Guionnet JM,Paboeuf F,Vial L,Le Potier MF

更新日期：2020-03-11 00:00:00

abstract：:Interferon-inducible transmembrane proteins (IFITM1/2/3) have been reported to suppress the entry of a wide range of viruses. However, their antiviral functional residues and specific mechanisms are still unclear. Here, we firstly resolved the topology of IFITM1 on the plasma membrane where N-terminus points into the ...

journal_title：Viruses

authors： Sun F,Xia Z,Han Y,Gao M,Wang L,Wu Y,Sabatier JM,Miao L,Cao Z

更新日期：2020-03-08 00:00:00

abstract：:Purinergic receptors are inflammatory mediators activated by extracellular nucleotides released by dying or injured cells. Several studies have described an important role for these receptors in HIV-1 entry, particularly regarding their activity on HIV-1 viral membrane fusion. Several reports identify purinergic recep...

journal_title：Viruses

authors： Freeman TL,Swartz TH

更新日期：2020-03-07 00:00:00

abstract：:Hepatitis B virus (HBV) infection affects ~350 million people and poses a major public health problem worldwide. HBV is a major cause of cirrhosis and hepatocellular carcinoma. Fewer than 5% of HBV-infected adults (but up to 90% of HBV-infected infants and children) develop chronic HBV infection as indicated by contin...

journal_title：Viruses

authors： Megahed FAK,Zhou X,Sun P

更新日期：2020-03-05 00:00:00

abstract：:Geminiviruses are important plant pathogens that affect crops around the world. In some geminivirus-host interactions, infected plants show recovery, a phenomenon characterized by symptom disappearance in newly emerging leaves. In pepper-Pepper golden mosaic virus (PepGMV) interaction, the host recovery process involv...

journal_title：Viruses

authors： Rodríguez-Gandarilla MG,Rodríguez-Negrete EA,Rivera-Bustamante RF

更新日期：2020-03-05 00:00:00

abstract：:Background: Bats are known to host a number of nonpathogenic viruses, as well as highly pathogenic viruses causing fatal diseases like rabies. Serological surveys as part of active and passive bat rabies surveillance mainly use seroneutralization assays, demonstrating the presence of lyssavirus-specific antibodies in ...

journal_title：Viruses

authors： Orłowska A,Smreczak M,Freuling CM,Müller T,Trębas P,Rola J

更新日期：2020-02-28 00:00:00

abstract：:One hundred Prunus trees, including almond (P. dulcis), apricot (P. armeniaca), nectarine (P. persica var. nucipersica), peach (P. persica), plum (P. domestica), purple leaf plum (P. cerasifera) and sweet cherry (P. avium), were selected from growing regions Australia-wide and tested for the presence of 34 viruses and...

journal_title：Viruses

authors： Kinoti WM,Nancarrow N,Dann A,Rodoni BC,Constable FE

更新日期：2020-02-23 00:00:00

abstract：:The degree of antigenic drift in swine influenza A viruses (swIAV) has historically been regarded as minimal compared to that of human influenza A virus strains. However, as surveillance activities on swIAV have increased, more isolates have been characterized, revealing a high level of genetic and antigenic differenc...

journal_title：Viruses

authors： Ryt-Hansen P,Pedersen AG,Larsen I,Kristensen CS,Krog JS,Wacheck S,Larsen LE

更新日期：2020-02-23 00:00:00

abstract：:Infectious bursal disease (IBD) is an immunosuppressive, highly contagious, and lethal disease of young chickens caused by IBD virus (IBDV). It results in huge economic loss to the poultry industry worldwide. Infection caused by very virulent IBDV (vvIBDV) strains results in high mortality in young chicken flocks. How...

journal_title：Viruses

authors： Yang B,Yan N,Liu A,Li Y,Chen Z,Gao L,Qi X,Gao Y,Liu C,Zhang Y,Cui H,Li K,Pan Q,Wang Y,Wang X

更新日期：2020-02-23 00:00:00

abstract：:In Europe, cowpox virus (CPXV) infection in South American camelids occurs as a so-called spill-over infection. Although infected animals generally have a mild form of the disease and survive, cases of fatal generalised CPXV infection have also been described. Prevention by prophylactic vaccination is the only way to ...

journal_title：Viruses

authors： Prkno A,Hoffmann D,Kaiser M,Goerigk D,Pfeffer M,Winter K,Vahlenkamp TW,Beer M,Starke A

更新日期：2020-02-20 00:00:00

abstract：:With ongoing colony losses driven in part by the Varroa mite and the associated exacerbation of the virus load, there is an urgent need to protect honey bees (Apis mellifera) from fatal levels of virus infection and from the non-target effects of insecticides used in agricultural settings. A continuously replicating c...

journal_title：Viruses

authors： Guo Y,Goodman CL,Stanley DW,Bonning BC

更新日期：2020-02-20 00:00:00

abstract：:Papaya ringspot virus (PRSV), a common potyvirus infecting papaya plants worldwide, can lead to either antagonism or synergism in mixed infections with Papaya mosaic virus (PapMV), a potexvirus. These two unrelated viruses produce antagonism or synergism depending on their order of infection in the plant. When PRSV is...

journal_title：Viruses

authors： Vargas-Mejía P,Vega-Arreguín J,Chávez-Calvillo G,Ibarra-Laclette E,Silva-Rosales L

更新日期：2020-02-19 00:00:00

abstract：:Influenza A viruses (IAV) have been a major public health threat worldwide, and options for antiviral therapy become increasingly limited with the emergence of drug-resisting virus strains. New and effective anti-IAV drugs, especially for highly pathogenic influenza, with different modes of action, are urgently needed...

journal_title：Viruses

authors： Ye M,Liao Y,Wu L,Qi W,Choudhry N,Liu Y,Chen W,Song G,Chen J

更新日期：2020-02-18 00:00:00

abstract：:Porcine circovirus 3 (PCV3) has been identified as a putative swine pathogen with a subset of infections resulting in stillborn and mummified fetuses, encephalitis and myocarditis in perinatal, and periarteritis in growing pigs. Three PCV3 isolates were isolated from weak-born piglets or elevated stillborn and mummifi...

journal_title：Viruses

authors： Mora-Díaz J,Piñeyro P,Shen H,Schwartz K,Vannucci F,Li G,Arruda B,Giménez-Lirola L

更新日期：2020-02-16 00:00:00

abstract：:Food security is currently a global socio-political pressure point that is exacerbated by the everincreasing world population[...]. ...

journal_title：Viruses

authors： Mahony J,Casey E,van Sinderen D

更新日期：2020-02-13 00:00:00

abstract：:In July 2018, a novel avian influenza virus (A/Mandarin duck/South Korea/KNU18-12/2018(H11N9)) was isolated from Mandarin ducks in South Korea. Phylogenetic and molecular analyses were conducted to characterize the genetic origins of the H11N9 strain. Phylogenetic analysis indicated that eight gene segments of strain ...

journal_title：Viruses

authors： Tuong HT,Nguyen NM,Sung HW,Park H,Yeo SJ

更新日期：2020-02-12 00:00:00

abstract：:Microvirin (MVN) is one of the human immunodeficiency virus (HIV-1) entry inhibitor lectins, which consists of two structural domains sharing 35% sequence identity and contrary to many other antiviral lectins, it exists as a monomer. In this study, we engineered an MVN variant, LUMS1, consisting of two domains with 10...

journal_title：Viruses

authors： Shahid M,Qadir A,Yang J,Ahmad I,Zahid H,Mirza S,Windisch MP,Shahzad-Ul-Hussan S

更新日期：2020-02-11 00:00:00

abstract：:Peste des petits ruminants virus (PPRV) causes a contagious disease of high morbidity and mortality in global sheep and goat populations. To better control this disease and inform eradication strategies, an improved understanding of how PPRV transmission risk varies by age is needed. Our study used a piece-wise cataly...

journal_title：Viruses

authors： Herzog CM,de Glanville WA,Willett BJ,Cattadori IM,Kapur V,Hudson PJ,Buza J,Swai ES,Cleaveland S,Bjørnstad ON

更新日期：2020-02-07 00:00:00

abstract：:: Rabies virus (RABV) is the only lyssavirus known to be present within the Caribbean. The island of Trinidad, is richly diverse in chiropteran fauna and endemic for bat-transmitted rabies with low RABV isolation rates observed in this population. We aimed to determine the seroprevalence of rabies virus neutralizing a...

journal_title：Viruses

authors： Seetahal JFR,Greenberg L,Satheshkumar PS,Sanchez-Vazquez MJ,Legall G,Singh S,Ramkissoon V,Schountz T,Munster V,Oura CAL,Carrington CVF

更新日期：2020-02-05 00:00:00

abstract：:Non-human primates (NHP) are the only animal model suitable to evaluate the protection efficacy of HIV-1 vaccines. It is important to understand how and when neutralizing antibodies (nAbs) with specificities similar to those of human broadly neutralizing antibodies (bnAbs) develop in NHPs. To address these questions, ...

journal_title：Viruses

authors： Gao N,Gai Y,Meng L,Wang C,Zhang X,Wang W,Qin C,Yu X,Gao F

更新日期：2020-01-31 00:00:00

abstract：:Usutu virus (USUV) is a neurotropic flavivirus closely related to West Nile virus (WNV). Its enzootic cycle mainly involves mosquitoes and birds. Human infection can occur with occasional, but sometimes severe, neurological complications. Since its emergence and spread in Europe over the last two decades, USUV has bee...

journal_title：Viruses

authors： Benzarti E,Rivas J,Sarlet M,Franssen M,Desmecht D,Schmidt-Chanasit J,Savini G,Lorusso A,Van Laere AS,Garigliany MM

更新日期：2020-01-31 00:00:00